Ampicillin and Sulbactam for Injection Dosage Guide for Patients with Renal Impairment

Creatinine Clearance
Half-Life (Hours)
RecommendedAmpicillin and
Sulbactamfor Injection Dosage
≥30 1 1.5 g to 3 g q 6 h to q 8 h
15 to 29 5 1.5 g to 3 g q 12 h
5 to 14 9 1.5 g to 3 g q 24 h
  1. Pan-resistant organism as per culture report with evidence of invasive disease – fever/ leucocytosis/elevated procalcitonin (PCT) or culture from a sterile site.
  2. Clinical failure of all other classes of antibiotics over 72 hours


Urinary Tract Infections

Skin and Skin Structure Infections

Intra-Abdominal Infections

Gynecologic Infections

High-dose ampicillin-sulbactam can be an alternative treatment of late-onset VAP from multidrug-resistant Acinetobacter baumannii

Ampicillin & Sulbactam for Injection